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Meeting of the General Assembly 2019

posted Mar 5, 2019, 10:57 PM by Rachel Aronoff   [ updated Mar 5, 2019, 11:02 PM ]

Here it is, almost time for our 6th AGiR! General Assembly Meeting!
Can you join us in Ecublens, in the new 'Espace Créateur' to help?
Come to the Route de Crochy 20 at 6:30 pm on April 3rd.
If you can't come in person, use the contact form, and we can arrange your virtual presence!

Help make genomic integrity understood by the public!

See the provisional agenda below.

Presentation at Utopiana

posted Feb 27, 2019, 12:41 AM by Rachel Aronoff   [ updated Feb 27, 2019, 12:43 AM ]

What a great evening at Utopiana in Geneva yesterday, talking about citizen science and the plans for the cheek cell chips!
Thanks to Anna for the invitation and to the participants for their questions and comments!
(Hoping someone will be inspired enough to submit something for the Art Call - which is still open for all, btw! :)


Workshops in Bilbao!

posted Jan 16, 2019, 12:46 PM by Rachel Aronoff   [ updated Jan 17, 2019, 6:17 AM ]

Very excited for the opportunity to do workshops in Bilbao this weekend!  
Here is the info: https://bbkopenscience.com/


2019 Ahead!

posted Dec 26, 2018, 9:40 AM by Rachel Aronoff   [ updated Dec 26, 2018, 9:40 AM ]

Have a great end to 2018!!
Here's hoping that 2019 will be the year during which many more realise the easy things they can do to protect themselves and their loved ones!!
Take care! 

The Seventh Women in Science Switzerland Luncheon

posted Nov 8, 2018, 10:34 AM by Rachel Aronoff   [ updated Nov 13, 2018, 3:07 AM ]

What a nice afternoon in Montreux with the attendees of the 7th annual Women in Science Switzerland Luncheon, hosted by Lola Grace and highlighted by the talk of Claudia Bagna on 'Intellectual and Social Disabilities: from Molecules to Behavior.'  Her talk centered on Fragile X syndrome and autism, with some interesting points also about Alzheimer's disease, brain development and enriched environments.  I always thought of Fragile X syndrome as being less central to autism, but it turns out to be involved in about 60% of cases and the other 30% are due to an interacting protein, together regulating gene expression at synapses.  Again, from a certain perspective, one could say it is all about dynamics of genomic integrity!  The main Fragile X protein (FMR1) leads to disease when it is not expressed  (as for the BRCA genes, which in contrast are important for correct DNA repair), and the molecular mechanisms for the gene being 'turned off' (trinucleotide repeats) are well known in other diseases also (but not always affecting whether a gene is expressed or not). Again this is genomic integrity being affected, in this case at the DNA level.  

Most importantly, the neuronal connections between cells (especially dendritic spines at synapses, where localised translation can occur) are disrupted in the absence of FMR1, because the regulation of its target genes is disrupted, leading to incorrect responses to cell activation and faulty synapses.  Such 'synaptopathies' can lead to many diseases affecting brain development, cognitive function and neurodegeneration. 

The extra points in the talk about patient families and how women in science are being helped by research to help understand interview biases were also very appreciated.  

If you were there, and wonder about the AGiR! chocolate in your goodie bag, and, especially, would like to get more, maybe even to give to your friends during the upcoming holiday season, please write biolab@hackuarium.ch before 30 November, or phone directly to the master chocolate maker (from Gruyère)!  His dark chocolates, we hope, are full of flavanols that may protect genomic integrity.  The idea to do a real test of whether eating such chocolate protects genomic integrity isn't new, but maybe the current micronuclei protocols at Hackuarium (even though currently 'without walls') would allow a real test of this sometime soon.  I know that is some 'citizen science' that could get a lot of volunteers!  
Let me know if you would like to join in... :)  

Genomic integrity and Open Science in China

posted Oct 11, 2018, 4:51 PM by Rachel Aronoff   [ updated Oct 12, 2018, 9:39 PM ]

It is very exciting to be participating in GOSH2018 this year, especially looking into open-source epifluorescence possibilities during a workshop yesterday! Perhaps the group from Bath, UK has a real possibility with an updated version of their OpenFlexure scope to move the comet cell data acquisition forward! (fingers crossed!) 

Meeting members of the public was especially interesting yesterday, at xfactory! (thanks, Violet, for allowing the great party, too!).  After such discussions, I really need to make good on my pledge to update this site, to another platform, it is clear; and I am putting the new flyer translation into the Hackuarium wiki, to make sure more people can see this and share its ideas (and I include the even smaller file here, as a preview, for those who can access it here).
(thanks again to Yanwu, Vivi, and others for their help and discussions !! Maybe one day in the not too distant future there will even be a Chinese side to this AGiR! site, as the issues are so crucial to all of us.)

It will also a great honour to be able to present the Hackuarium genomic integrity projects at the Shenzhen Maker Week-GOSH conference (Oct.14) to end the trip!
Hoping the #GOSH2018 Prezi goes smoothly! :)

 万岁开放的科学! 
(Long live open science!)

Comet Assays and More

posted Aug 22, 2018, 1:54 AM by Rachel Aronoff   [ updated Aug 22, 2018, 3:11 PM ]


The Hackuarium projects to more readily allow people to detect DNA damage in their own cheek cells have gotten new life with interns, Violaine Regard, Jennifer Veillard, and Vithooban Thavapalan, working hard in the lab!  
Maybe they will be able to tell us about the 'cheek cell chip' prototype soon?
They are also working towards automatic detection of micronuclei, to aid towards counting the 1000 cells!  (Workshop participants know what a challenge that can be!)
 
Save the Date!  A special event is planned for the evening of September 26 at Hackuarium, #OpenHackuarium 221, with Dr. Delphine Plaire telling us about her studies on DNA damage, and the students presenting short summaries of their results! 

Come learn more!

and take care!!  

Ageing, too!

posted Jun 16, 2018, 12:44 AM by Rachel Aronoff   [ updated Jun 16, 2018, 12:47 AM ]

 Looking forward to a big symposium next week at the UNIL CIG!
 There will be an evening public talk too - also sponsored by Women in Science!
 Of course, genomic integrity is also important for this topic!!  Some latest research includes findings on telomeres and the DNA damage response...  
 Maybe see you there?

Take care!

More Art!

posted May 7, 2018, 1:22 AM by Rachel Aronoff   [ updated Jun 9, 2018, 1:54 AM ]

Happy to announce that David Goodsell from the Scripps Research Institute and the RCSB Protein Data Bank is contributing more amazing molecular art for the AGiR! Art Call!  
&
He says we can choose our favorites!!

Here is a little taste:  

showing the Cas9 protein bound to CRISPR RNA (red) and a target viral DNA (yellow)

Look for more here soon! (in the Art Call Works page!)

Additionally, some of you might have already seen the first video attempt from the last workshop at Hackuarium.  Some might call this art... ;) 
I really have to thank the Patiny family for helping us get the super timelapse...  (at least 1.5h in 33s!)



Another Cheek Cell Micronucleus Assay Workshop!

posted Apr 3, 2018, 1:25 AM by Rachel Aronoff   [ updated Apr 3, 2018, 1:26 AM ]

This one will be in Renens (near Lausanne, Switzerland) at Hackuarium, an open public lab that wants to democratise science for all, on 21April.
 Sign up with a friend and learn more!!
Looking forward to seeing you there!


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