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Postponing General Assembly Meeting - to the 23rd of April

posted by Rachel Aronoff   [ updated ]

 With everything happening, we will postpone the 2020 General Assembly for AGiR! as a Swiss public association, holding the meeting (most likely still virtually - sign up with the contact link) on the 23rd of April.  
 This is the day after Earth Day, by the way... Let's see what can be done to help...

General Assembly

posted Mar 6, 2020, 6:48 AM by Rachel Aronoff   [ updated Mar 6, 2020, 7:08 AM ]


  The general assembly meeting for the association AGiR! will be 2 April, at Hackuarium
19h, at Route de Crochy 20 in Ecublens.
  If you want to attend virtually, please contact us, and we can set it up!
(or if you want to vote but don't have the time to attend really or virtually - or you are in the wrong timezone - you can sign a 'procuration' form to join in!  The agenda will soon be available.)

and in the meantime, 
take care!
you might enjoy thinking about genomic integrity and ageing (rather than disease...), right?  
(unless you think ageing really is a kind of disease one might treat?)

It is clear that disruption of genomic integrity at so many levels can accelerate ageing, not just crosslinking effects, as often exemplified with this image (also by David Sinclair of the sirtuins =)! ) of a truck driver, after a career of about 25 years:

maybe future AGiR! actions could include a specific ageing working group?
sound interesting? 
Anyone, even a non-member, is welcome to the general assembly meeting, but only members can vote.
Maybe you will even be inspired to join in, providing information and promoting research!

Ageing Better

posted Feb 1, 2020, 2:54 AM by Rachel Aronoff   [ updated Feb 1, 2020, 2:56 AM ]

One point about dynamic genomic integrity: impact doesn't necessarily need actual mutations (although of course these can be important for developing chronic diseases).  Still, epigenetic changes or just clogging/crosslinking can be sufficient for real problems.  

And this leads me to some very cute ideas about all this for 'healthy ageing' - another great reason to protect your genomic integrity by avoiding what might cause problems.  For instance, as discussed by David Sinclair (of sirtuin research and more), when DNA is damaged and has to get repaired, a bunch of epigenetic tags, both on DNA itself and on the histones that DNA is wrapped around (to affect gene expression), can 'get screwed up, so cells get confused' !
The hypothesis is that poor ageing is a side-effect of this...

Maybe these ideas will make people more interested in AGiR! ??
A focus on disease is most likely less popular than ideas about 'living well' and well into your 10th decade, this day and age, in particular...

What do you think? 
Take care!

One more thing:
Please check out our latest blog post, to see what's been going on at the Hackuarium lab, recently, for genomic integrity and AGiR!  Everyone is welcome to join in for these open science studies, by the way! :)

The New '2020s' - a Decade for Genomic integrity!

posted Dec 20, 2019, 2:10 AM by Rachel Aronoff   [ updated Dec 27, 2019, 8:30 AM ]

Happy holidays!!

  Hoping they are a joy for all, and especially that the message about protecting genomic integrity really makes an impact in the next decade!!

  Let's make the 'new '20s' the best ever...  for health and the environment, too!
Why not?  Find out how we are making 'open science' efforts in this regard, by checking out the latest blog post!

Hoping for us all - 2020 will get everyone knowing about these ideas!

Enjoy the chocolates, too!  
(tell me if there are any problems regarding packages in the mail...)
chocolates 2019

Chocolate Sale

posted Nov 18, 2019, 1:24 PM by Rachel Aronoff   [ updated Dec 2, 2019, 9:37 AM ]

A super holiday gift - artisanal 'grand cru' chocolates from Gruyère - is on sale to fundraise for our public association, AGiR! Action for Genomic integrity through Research!

Genomic integrity, the concept putting together all the dynamic molecular genetic details of our cells, is now 10 years old.

Your purchase of chocolates can help AGiR! continue providing information and promoting research, the main goals of of the association. We hope to help everyone understand why some risks are problematic (and could be readily avoided) for public health.

Spread the word by telling your friends about this chocolate sale.
(SVP commander en français avant le 6déc19)

Women In Science

posted Nov 1, 2019, 1:37 AM by Rachel Aronoff   [ updated Nov 12, 2019, 8:20 AM ]

Looking forward to another luncheon event in Montreux for our local Women In Science group on the 12th of November, with Professor Solange Peter, who will present her work about
Treating Cancer Today:
Innovations, Promises and Limitations

In further news:  We are considering selling delicious artisanal chocolates for fundraising!  
Fill in the form before 6 December 2019!

Making DNA up for Grabs!?

posted Oct 19, 2019, 10:23 AM by Rachel Aronoff   [ updated Nov 17, 2019, 3:39 AM ]

So excited by the amazing work in Vibrio cholerae by an old UNIL colleague, Noémie Matthey, who presented her thesis work at the EPFL last week!  Illustrated by her own gorgeous and clear art-work, her public defence was a triumph in presenting molecular microbiological results for the general public.
Their open science article in eLife just came out, but we can expect more amazing revelations, I am sure... 

So many are super keen on the CRISPR system, used by bacteria to defend against foreign DNA (and now by biologists to chose what they would like to modify/repair!), but who would have thought that bacteria would be killing each other to acquire DNA from other species to enhance their capacity for evolving new functions!? 

Apparent regulation not only of the killing and lasso-ing mechanisms, but of an extracellular nuclease by these microbes, makes this activity seem almost a 'conscious' mechanism for disrupting or enhancing genomic integrity, depending upon whether the bug is the one killed or doing the killing!  ;)

Hoping to learn more soon!

More Languages for the Flyer!

posted Jul 24, 2019, 4:39 AM by Rachel Aronoff   [ updated Oct 19, 2019, 2:14 PM ]

 So glad to have had help for more super languages for the flyer - to be posted soon!!

 The flyer has a very simple message, and we hope it will help spread the word even further, with Malay, Indonesian, Marathi and more!!!  Big Thanks to Kelly from Singapore!  (and now there is already a new flag on the site, too!!)

 There's nothing like interest to help inspire more updates to this old site!
(use the contact link if *you* want to join in!)
Take care!

Open Science in Columbia

posted Jun 21, 2019, 9:14 PM by Rachel Aronoff   [ updated Jun 21, 2019, 9:21 PM ]

 So excited to be in Colombia and talking about genomic integrity and open science!

 Mercury is a big topic in the country, and more may be learned soon!!

 Thanks to our hosts and new friends!  Hoping to have the opportunity to explore further together!

Special Keynote Lecture (and P1 again!)

posted Jun 6, 2019, 5:34 AM by Rachel Aronoff   [ updated Jun 21, 2019, 9:25 PM ]

There are two special news items today!
 Next Thursday, 13June, there will be a keynote lecture at a UNIL symposium, entitled Sugar and cancer: not a sweet story! by Lewis C. Cantley from Cornell.  Sponsored by the Grace family, I am really looking forward to this!   Here is the program for the full symposium, with lots of interest in terms of dynamics of genomic integrity!
Additionally, some even bigger news: the lab of Hackuarium can again do P1 (biosafety level 1) experimentation, after an inspection today.  Maybe I am really going to learn more about how synthetic biology isn't just another word for molecular biology?? :)

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