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posted Oct 1, 2020, 10:49 AM by Rachel Aronoff   [ updated Oct 1, 2020, 10:49 AM ]



amazing encounters - coincidencia y investigation participative for change

ENTANGLEMENTS evidenced :)

XPRIZE Semi-finals for Corona Detective

posted Sep 15, 2020, 5:49 AM by Rachel Aronoff   [ updated Sep 23, 2020, 3:46 AM ]

 More exciting times in the midst of the pandemic keep coming...  Now we are getting ready for the semi-finals of the XPrize!  For more info, here is a Medium post from colleagues from JOGL.  Seems likely that participating in this will provide a stringent test for the 'no cold chain dependence' aspect of the method - with colleagues from Sri Lanka set to test in parallel with the team in Paris.  Fingers crossed that we make it to the Finalist stage, when 20 teams' methods will be used for large-scale clinical validation!

 In the meantime, take care!

Multiplex for #CoronaDetective

posted Jul 31, 2020, 10:38 AM by Rachel Aronoff   [ updated Aug 2, 2020, 12:34 PM ]

As the pandemic continues, we are happy to know that the molecular detection of SARS CoV-2 has achieved a special milestone, so-called 'multiplex detection' of two different targets at once, one an internal control to show the extraction and reaction were both good, and the other for detecting the virus causing Covid-19.  
This is a big deal, because it means one 8-tube strip can analyse 5 different samples, not just 2. 
The team is gearing up to send detectors off to colleagues (Guy in Paris) and test more target combinations (two different internal controls and another viral one, Rachel -me- in Lausanne).
Ultimately the best combination of control and viral target reaction components will be freeze-dried in Paris and sent to colleagues (in many sites, from Chile to Cameroon and Germany to Ghana) for validation.
The 96-well format can also be tested, for scaling up capacity, particularly if labs have BSL2/3 and plate readers!
Fingers crossed, our efforts, begun as a project in the OpenCovid-19 Initiative, will be of help far and wide.

In the meantime, take care! 

It's easy to remember the 3 Ws.  
Wash hands before touching your face! 
Wear masks!
Watch your physical distances (at least 2m or 6ft - and if not, must have masks)!


Feeling sidetracked by Corona?

posted May 28, 2020, 12:10 AM by Rachel Aronoff   [ updated May 28, 2020, 12:35 AM ]

 Well, we have been, too...

Still, AGiR! is very glad to be able to contribute, especially with some sequence gazing and testing to develop simpler molecular assays!  We've joined in for amazing collaborative research with colleagues from around the world, in particular working towards the #CoronaDetective - analogous to the GMO Detective, of course!

(However, I have also been glad to have been able to talk about participatory research recently!  
& We still hope the cheek cell chip in the context of the OpenFlexure scope will come together, eventually...)

Hoping in the end this pandemic is not too painful for us all, and we somehow come out of it better.  Time to make the change!

You can contribute, too!  
All kinds of needs, not just biology, require support...

Hoping to see you in the Hackuarium lab (even virtually), a slack, some zoom (Qi Gong!) or once again out and about, in the not too distant future.

Take care!

Moving forward, virtually and really!

posted Apr 27, 2020, 1:47 AM by Rachel Aronoff   [ updated Apr 27, 2020, 1:48 AM ]

The general assembly meeting went well last week, with 9 different computers on the zoom connection, including two from outside the country (one with two founding members, who were 'attending' their first such meeting!), and unanimous votes to help us move forward as an association to make more international impact.  
Probably we will not only try to become an association of 'public utility' this year, but organise a bigger and better chocolate sale!  =) 
In addition, plans for more work to open-source the DNA damage assays and develop the 'cheek cell chip' for both micronuclei and comets and more

Thank you to all the participants (and also to those who took the time to excuse themselves for not being able to come!)!

In other news, AGiR! is very happy to be able to try to make a difference in this strange time, working towards a SARS CoV-2 detection strategy, the #CoronaDetective (think doorknobs though, and general environmental monitoring, not clinical diagnostics!).  It's an exciting international collaboration, but as seemingly usual, chance and the OpenCovid-19 Initiative helped bring everything together...  
There are many 'needs' for all sorts of projects there, if you are looking for something to do in these strange times.

Take care!


Postponing General Assembly Meeting - to the 23rd of April

posted Mar 31, 2020, 1:00 PM by Rachel Aronoff   [ updated Apr 19, 2020, 6:15 AM ]

 With everything happening, we will postpone the 2020 General Assembly for AGiR! as a Swiss public association, holding the meeting (most likely still virtually - sign up with the contact link) on the 23rd of April.  
 This is the day after Earth Day, by the way... Let's see what can be done to help...
 
It is confirmed: 8pm on the 23rd - use contact here, please to tell me if you want the zoom link, but are not (yet) an active member! :)

General Assembly

posted Mar 6, 2020, 6:48 AM by Rachel Aronoff   [ updated Mar 6, 2020, 7:08 AM ]

SHOW UP, SPEAK OUT!


  The general assembly meeting for the association AGiR! will be 2 April, at Hackuarium
19h, at Route de Crochy 20 in Ecublens.
  If you want to attend virtually, please contact us, and we can set it up!
(or if you want to vote but don't have the time to attend really or virtually - or you are in the wrong timezone - you can sign a 'procuration' form to join in!  The agenda will soon be available.)

and in the meantime, 
take care!
you might enjoy thinking about genomic integrity and ageing (rather than disease...), right?  
(unless you think ageing really is a kind of disease one might treat?)
:)

It is clear that disruption of genomic integrity at so many levels can accelerate ageing, not just crosslinking effects, as often exemplified with this image (also by David Sinclair of the sirtuins =)! ) of a truck driver, after a career of about 25 years:

maybe future AGiR! actions could include a specific ageing working group?
sound interesting? 
 
Anyone, even a non-member, is welcome to the general assembly meeting, but only members can vote.
Maybe you will even be inspired to join in, providing information and promoting research!
AGiR!  ACT!


Ageing Better

posted Feb 1, 2020, 2:54 AM by Rachel Aronoff   [ updated Feb 1, 2020, 2:56 AM ]

One point about dynamic genomic integrity: impact doesn't necessarily need actual mutations (although of course these can be important for developing chronic diseases).  Still, epigenetic changes or just clogging/crosslinking can be sufficient for real problems.  

And this leads me to some very cute ideas about all this for 'healthy ageing' - another great reason to protect your genomic integrity by avoiding what might cause problems.  For instance, as discussed by David Sinclair (of sirtuin research and more), when DNA is damaged and has to get repaired, a bunch of epigenetic tags, both on DNA itself and on the histones that DNA is wrapped around (to affect gene expression), can 'get screwed up, so cells get confused' !
The hypothesis is that poor ageing is a side-effect of this...

Maybe these ideas will make people more interested in AGiR! ??
A focus on disease is most likely less popular than ideas about 'living well' and well into your 10th decade, this day and age, in particular...

What do you think? 
Take care!


One more thing:
Please check out our latest blog post, to see what's been going on at the Hackuarium lab, recently, for genomic integrity and AGiR!  Everyone is welcome to join in for these open science studies, by the way! :)

The New '2020s' - a Decade for Genomic integrity!

posted Dec 20, 2019, 2:10 AM by Rachel Aronoff   [ updated Dec 27, 2019, 8:30 AM ]

Happy holidays!!

  Hoping they are a joy for all, and especially that the message about protecting genomic integrity really makes an impact in the next decade!!

  Let's make the 'new '20s' the best ever...  for health and the environment, too!
Why not?  Find out how we are making 'open science' efforts in this regard, by checking out the latest blog post!

Hoping for us all - 2020 will get everyone knowing about these ideas!

Enjoy the chocolates, too!  
(tell me if there are any problems regarding packages in the mail...)
chocolates 2019

Chocolate Sale

posted Nov 18, 2019, 1:24 PM by Rachel Aronoff   [ updated Dec 2, 2019, 9:37 AM ]

A super holiday gift - artisanal 'grand cru' chocolates from Gruyère - is on sale to fundraise for our public association, AGiR! Action for Genomic integrity through Research!


Genomic integrity, the concept putting together all the dynamic molecular genetic details of our cells, is now 10 years old.

Your purchase of chocolates can help AGiR! continue providing information and promoting research, the main goals of of the association. We hope to help everyone understand why some risks are problematic (and could be readily avoided) for public health.

Spread the word by telling your friends about this chocolate sale.
(SVP commander en français avant le 6déc19)

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